
Ro 90-7501
CAS No. 293762-45-5
Ro 90-7501 ( —— )
产品货号. M33482 CAS No. 293762-45-5
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维组装抑制剂,可降低 Aβ42 诱导的细胞毒性 (EC50 为 2 μM)。Ro 90-7501 抑制 ATM 磷酸化和 DNA 修复。RO 90-7501选择性增强 TLR3和 RLR 配体诱导的 IFN-β 基因表达和抗病毒反应。Ro 90-7501 还以 TPR 依赖性方式抑制蛋白磷酸酶 5 (PP5),并对宫颈癌细胞具有显着的放射增敏作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥388 | 有现货 |
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5MG | ¥549 | 有现货 |
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10MG | ¥993 | 有现货 |
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25MG | ¥2127 | 有现货 |
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50MG | ¥3621 | 有现货 |
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100MG | ¥6021 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ro 90-7501
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维组装抑制剂,可降低 Aβ42 诱导的细胞毒性 (EC50 为 2 μM)。Ro 90-7501 抑制 ATM 磷酸化和 DNA 修复。RO 90-7501选择性增强 TLR3和 RLR 配体诱导的 IFN-β 基因表达和抗病毒反应。Ro 90-7501 还以 TPR 依赖性方式抑制蛋白磷酸酶 5 (PP5),并对宫颈癌细胞具有显着的放射增敏作用。
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产品描述Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner.Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
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体外实验——
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体内实验Animal Model:Female BALB/c nude mice (8-week-old) with HeLa cells underirradiation Dosage:5 μg/g Administration:Intraperitoneal injection; daily; for 21 days Result:Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点ATM/ATR
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受体ATM/ATR | Apoptosis | Phosphatase | Gamma-secretase
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研究领域——
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适应症——
化学信息
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CAS Number293762-45-5
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分子量340.38
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分子式C20H16N6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 41.67 mg/mL (122.42 mM; 超声助溶 )
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SMILESNC1=CC=C(C=C1)C1=NC2=C(N1)C=C(C=C2)C1=NC2=C(N1)C=C(N)C=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810.?